Research Stuff

I worked initially on chromatin structure, epigenetics and cell division. My PhD thesis was mainly focused on NH₂-terminal domain of the centromeric histone variant CENP-A. I showed that the mitotic phosphorylation of that domain is required for the correct segregation of chromosomes in HeLa cells and for the centromeric localization of CENP-C.

Of note, parts of those results have been later convincingly contradicted by others (Barra et al., 2019).

During my PhD, I was also involved in research regarding the structure of the nucleosome and the chromatin fiber (Syed et al., 2010, Shukla et al., 2011, and Meyer et al., 2011), and to a lesser extent in work on the transcriptional regulation of ATAD2 (Altintas et al., 2012).

After my PhD, I spent a few years still working on cell division and DNA repair. I was particularly interested in the mechanisms which allow broken chromosomes to be properly segregated in mitosis (Derive et al., 2015), using both cultured human cells and fruit flies as model organisms.

I am now interested in the biology of brain tumors and particularly glioblastoma multiforme (GBM). I am using fruit flies to study the role of intratumor heterogeneity in tumor development and resistance to chemotherapy, and also the pathways involved in the regulation of tumourigenic growth (Fernández-Espartero et al., 2018).